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10.1038/nri2454 Nat Rev Immunol

If your foot is swollen, red, and warm but it doesn't really hurt you might think that's a good sign

Endo H, Niioka M, Kobayashi N, Tanaka M, Watanabe T (2013) Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis

However, these natural chemicals present significant therapeutic challenges, including low absorption rates, poor chemical stability, limited permeability, and risk of liver and kidney damage